If a father or mother of your proband is known to hold the pathogenic variant identified inside the proband, the danger into the sibs of inheriting the pathogenic variant is 50%. On account of reduced penetrance, sibs who inherit the pathogenic variant might or might not create aHUS (see Penetrance). https://ahu-s61592.elbloglibre.com/34387484/the-2-minute-rule-for-air-handling-unit-ahu-hire