In this article, we clearly show that conolidine, a organic analgesic alkaloid Employed in conventional Chinese drugs, targets ACKR3, therefore giving more evidence of a correlation between ACKR3 and soreness modulation and opening different therapeutic avenues to the treatment of Persistent pain. The 1st asymmetric complete synthesis of conolidine https://fletcherg035jfb4.popup-blog.com/profile